The 2022 CNBC Disruptor 50 list: Meet the next generation of Silicon Valley


In the tenth annual Disruptor 50 list, CNBC highlights private companies that grew through the ups and downs of the pandemic and are poised to meet increasing economic and consumer challenges.

All told, these firms have raised a half-trillion dollars in venture capital. At least 41 are unicorns, with valuations of $1 billion or more – 14 are valued at over $10 billion. But becoming a unicorn has become all too common, and as market volatility pressures valuations in both public and private markets, other stats stand out: 

Forty of the companies have a social or environmental purpose that is core to their business model. Ten of this year’s Disruptors are from the logistics sector, tackling the broken global supply chain that has fueled four-decade high inflation. Eight are reducing costs in a bloated health-care system and reaching underserved populations. Several more are dedicated to the climate crisis. Nine of this year’s Disruptors have a female founder. Sixteen feature CEOs from racial and ethnic minorities.  

The 50 companies selected using the proprietary Disruptor 50 methodology have raised over $56 billion in venture capital, according to PitchBook, at an implied Disruptor 50 valuation of more than $552 billion.

1 Flexport Overwhelming the supply chain bottleneck
2 Brex The start-up world’s finance department
3 Lineage Logistics On top of the global food supply’s temperature
4 Canva The feature presentation
5 Guild Education Work. Study.
6 Convoy Trucking as we’ve known it stops here
7 Web3’s dot com
8 Stripe Making the internet pay
9 Dapper Labs The shot Michael Jordan and Kevin Durant are taking on decentralization
10 Hand over the reins.
11 A rival to the Stripe swipe
12 Chime A challenger bank in a challenging fintech market
13 Discord How digital natives converse
14 Flock Freight Fully loaded
15 Medable The virtual clinical trial
16 Truepill The infrastructure for online pharmacy
17 Arctic Wolf A cyber defender from up north
18 CloudTrucks Big ideas for the Big Road
19 Maven Clinic Putting women first in health
20 Monarch Tractor 1 driver. 8 tractors. All electric.
21 Fanatics Taking sports merch into the metaverse
22 Tala The world’s local lender
23 Anduril Industries Engineering an autonomous military arsenal
24 Workato Office work automated
25 Lacework Cybercrime’s lie detector
26 Somatus Kidney care without the dialysis centers
27 Gopuff All your instant needs fulfilled
28 Virta Health Don’t treat diabetes; reverse it.
29 Zipline A life-saving drone, with a Walmart side hustle
30 CarbonCure Carbon to concrete
31 Jüsto Mexico’s answer to Walmart, and FreshDirect, and Gopuff
32 Biobot Analytics A wastewater virus hunter
33 Airtable The code for every knowledge worker
34 Databricks The start-up world’s biggest data bet
35 DataRobot A one-trillion predictions market maker
36 Relativity Space An Elon Musk reusable rocket competitor
37 NEXT Insurance Digital small business insurance
38 Ro Planning to be a digital health survivor
39 Airspace Critical on-demand delivery for the pandemic era
40 Thrasio A consumer products giant for the digital age.
41 Cybereason A bird’s eye view
42 BlocPower Building net-zero cities
43 ŌURA The one ring to rule wearables
44 MoonPay The biggest celebrity bet on crypto
45 Zum School bus magic
46 Exotec France’s warehouse robot unicorn
47 Plaid A bridge from fintech to bank
48 Cityblock Health Healthtech for low-income America
49 Impossible Foods From plant-based fad to fixture
50 Envoy Back to the office of the future

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